血清PTX3联合Sestrin2对感染性休克患者疾病转归的预测效能

目的 探讨血清正五聚蛋白3(PTX3)联合Sestrin2对感染性休克患者疾病转归的预测效能。方法选取2020年5月—2023年5月海口市人民医院收治的122例感染性休克患者作为研究组，连续随访28 d，根据预后生存情况分为存活组（83例）和死亡组（39例）。另取同期该院健康体检人群150例作为对照组。采用酶联免疫吸附试验检测血清PTX3、Sestrin2水平，受试者工作特性（ROC）曲线评估血清PTX3、Sestrin2对感染性休克患者预后的预测价值，多因素逐步Logistic回归模型探讨感染性休克患者预后的影响因素。结果 研究组血清PTX3、Sestrin2水平均高于对照组（P <0.05）。死亡组血清PTX3、Sestrin2水平均高于存活组（P <0.05）。ROC曲线结果分析显示，PTX3联合Sestrin2预测感染性休克患者预后的曲线下面积（AUC）最大，为0.904(95%CI:0.853,0.955)，特异性为85.68%(95%CI:0.838,0.948)，敏感性为84.26%(95%CI:0.884,0.932)。死亡组年龄≥60岁占比、SOFA评分、...

Predictive efficacy of serum PTX3 combined with Sestrin2 for disease outcome in patients with septic shock

Objective To explore the predictive efficacy of serum Pentraxin 3 (PTX3) combined with Sestrin2 for disease outcome in patients with septic shock.Methods A total of 122 patients with septic shock admitted to our hospital from May 2020 to May 2023 were selected as the study group, followed up for 28 days, and divided into survival group (n = 83) and death group (n = 39) according to the prognosis. In addition, 150 healthy people who underwent health checkup in our hospital during the same period were included as the control group. Serum levels of PTX3 and Sestrin2 were detected by enzyme-linked immunosorbent assay, and the predictive values of serum PTX3 and Sestrin2 for prognosis of patients with septic shock were assessed by receiver operating characteristic (ROC) curves. The factors affecting the prognosis of patients with septic shock were analyzed by multivariable stepwise Logistic regression.Results Serum levels of PTX3 and Sestrin2 in the study group were higher than those in the control group (P < 0.05). Serum levels of PTX3 and Sestrin2 in the death group were higher than those in the survival group (P < 0.05). ROC curve analysis showed that the area under the curve (AUC) of PTX3 combined with Sestrin2 for predicting the prognosis of patients with septic shock was the largest, which was 0.904 (95% CI: 0.853, 0.955), with a specificity of 85.68% (95% CI: 0.838, 0.948) and a sensitivity of 84.26% (95% CI: 0.884, 0.932). The proportion of patients with the age ≥ 60 years, SOFA score and APACHEⅡ score in the death group were higher than those in the survival group (P < 0.05), and the leukocyte count and serum levels of creatinine and procalcitonin in the death group were higher than those in the survival group (P < 0.05). The multivariable stepwise Logistic regression analysis (inclusion of variables with α < 0.05 and exclusion of variables with α > 0.10) revealed that high SOFA score [O^R = 2.022 (95% CI: 1.443, 2.832) ], high level of procalcitonin [O^R = 2.261 (95% CI: 1.577, 3.243) ], PTX3 ≥ 94.72 ng/mL [O^R = 3.019 (95% CI: 1.939, 4.702) ], and Sestrin2 ≥ 15.87 ng/mL [O^R = 2.617 (95% CI: 1.727, 3.965) ] were the prognostic factors for patients with septic shock (P < 0.05).Conclusion Serum PTX3 and Sestrin2 are highly expressed in patients with septic shock, and are biomarkers for predicting the prognosis of patients with septic shock, with the combination of the two indicators yielding higher predictive efficacy.