高良姜乙醇提取物微囊的制备及其性能表征

探究高良姜乙醇提取物微囊的最佳制备工艺及其性能表征。【方法】 以阿拉伯胶（GA）-壳聚糖（CS）为囊壁材料，采用复合凝聚法制备微囊，以载药量和包封率为指标，通过正交设计法筛选微囊最佳制备工艺，并采用高效液相色谱（HPLC）法测定微囊中高良姜乙醇提取物的含量，利用红外光谱仪及扫描电子显微镜对所制备的微囊进行性能表征。【结果】高良姜乙醇提取物微囊的最佳制备条件为壁材比（GA/CS）6∶1，芯壁比 1∶1，凝聚时间 45 min，固化剂用量 3 mL。此条件下制备高良姜乙醇提取物微囊的载药量为 27.17 %，包封率为 80.07%，且高良姜乙醇提取物微囊缓释性能优于高良姜乙醇提取物。【结论】 复合凝聚法制备高良姜乙醇提取物微囊具有较好的包封性，方法简单且稳定可靠，可行性高。

Preparation and Performance Characterization of Microcapsules Containing Ethanol Extract from Galangal

To explore the best preparation process and performance characterization of microcapsules containing ethanol extract from galangal. Methods With gum arabic（GA） -chitosan（CS） as capsule wall material，microcapsules were prepared by complex coacervation method. With drug loading and encapsulation efficiency as indexes， the optimal preparation technology of microcapsules was screened by orthogonal design method. The content of ethanol extract of galangal in microcapsules was determined by high performance liquid chromatography（HPLC）. The prepared microcapsules were characterized by infrared spectrometer and scanning electron microscope. Results The optimum preparation conditions of microcapsules containing galangal ethanol extract were as follows：wall material ratio（GA/CS）6∶1，core to wall ratio 1∶1，coagulation time 45 minutes，curing agent dosage 3 mL. Under these conditions， the drug loading and encapsulation efficiency of microcapsules containing galangal ethanol extract were 27.17% and 80.07%， respectively， and the sustained release performance of microcapsules of galangal ethanol extract was superior to that of galangal ethanol extract.Conclusion The preparation of microcapsules containing galangal ethanol extract by complex coacervation method has good encapsulation，and the method is simple，stable and reliable，and has high feasibility