微RNA在免疫性血小板减少症中参与调节免疫细胞的研究进展

微RNA是一类具有基因表达和调控功能的非编码RNA，参与多种生理过程，其异常表达与免疫性血小板减少症的发生密切相关。微RNA主要通过调节适应性和特异性免疫细胞来调控基因表达，进而影响免疫性血小板减少症中的免疫应答反应。本文就微RNA通过调节单核细胞、巨噬细胞、调节性T细胞、辅助性T细胞17、B细胞、调节性B细胞的表达影响免疫性血小板减少症病情变化的研究现状和进展进行综述，以期为未来治疗该病提供新思路、新靶点。

Research progress of microRNA involved in the regulation of immune cells in immune thrombocytopenia

MicroRNA is a class of non-coding RNA that have gene expression and regulation functions and is involved in many physiological processes. Their abnormal expression is closely related to the occurrence of immune thrombocytopenia. MicroRNA regulate gene expression mainly by regulating adaptive and specific immune cells, and affect the immune response in immune thrombocytopenia. This article reviews the current status and progress of research on the influence of microRNA on immune thrombocytopenia by regulating the expression of monocytes, macrophages, regulatory T cells, helper T cells 17, B cells, and regulatory B cells, in order to provide new ideas and new targets for future treatment of this disease.