Emotional behavior in aged neuropeptide Y (NPY) Y2 knockout mice |
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Authors: | Cristina Carvajal Yvan Dumont Herbert Herzog Rémi Quirion |
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Affiliation: | (1) Douglas Hospital Research Centre, Department of Neurology and Neurosugury, Department of Psychiatry, McGill University, H4H 1R3 Montréal, QC, Canada;(2) Garvan Institute of Medical Research, Darlinghurst, 2010 Sydney, NSW, Australia |
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Abstract: | Neuropeptide Y (NPY) was shown to modulate anxiety- and depression-related behaviors in various animal models. Previous studies demonstrated that NPY Y2 receptor knockout (KO) mice display an anxiolytic- and antidepressant-like phenotype compared with control animals. However, the long-term effect of the deletion of this receptor in aged animals is unknown. Thus, anxiety- and depression-related behaviors were investigated in 2-yr-old NPY Y2 KO mice. Aged NPY Y2 KO mice display an anxiolytic-like profile as assessed in the elevated plus-maze and open field, providing further support for a role for Y2 receptors in anxiety-related behaviors. Furthermore, aged NPY Y2 KO mice have significantly lower immobility scores in the forced swim test; supproting the role for this receptor in antidepressand-like behaviors. These data provide further evidence that modulators of the NPY Y2 receptor subtype are drug targets for the treatment of anxiety and mood disorders in human subjects. |
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Keywords: | Neuropeptide Y Y2 receptor knockout aging anxiety depression |
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