| 食管癌及癌旁组织端粒酶活性的原位检测 |
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| 引用本文： | 成静,钱晓彬,曹友清,陈淼.食管癌及癌旁组织端粒酶活性的原位检测[J].中国现代医学杂志,2002,12(24):65-66,69. |
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| 作者姓名： | 成静 钱晓彬 曹友清 陈淼 |
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| 作者单位： | 1. 江苏大学微免教研室,镇江,212001
2. 江苏大学病理教研室,镇江212001 |
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| 基金项目： | 江苏省科委社会发展项目 (编号 :BS2 0 0 0 3 93 ) |
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| 摘 要： | 目的 :研究端粒酶活性在食管癌、癌旁组织、正常粘膜中的定位表达情况。方法 :应用原位杂交技术 ,检测端粒酶的mRNA。结果 :食管癌组织中端粒酶阳性表达率为 (2 8/ 30 ) ,明显高于癌旁组织 (4/ 30 )和正常粘膜(0 / 30 )。结论 :原位杂交检测是一种特异、灵敏、简单、准确的端粒酶检测方法 ,端粒酶活性的原位表达是食管癌的一项有用的诊断指标。
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| 关 键 词： | 原位杂交 端粒酶活性 食管癌 |
TELOMERASE ACTIVITY DETECTED IN SITU IN ESOPHAGEAL CANCER AND ADJENCET CANCER TISSUES |
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| Cheng Jing.TELOMERASE ACTIVITY DETECTED IN SITU IN ESOPHAGEAL CANCER AND ADJENCET CANCER TISSUES[J].China Journal of Modern Medicine,2002,12(24):65-66,69. |
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| Authors: | Cheng Jing |
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| Institution: | Cheng Jing Department of Laboratory Immunology of Jiangsu University,Zhenjiang 212001 Qian Xiaobin,Cao Youqing,Chen Miao Department of Pathology of Jiangsu University,Zhenjiang 212001 |
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| Abstract: | Objective:Studying the expression of telomerase activity in the cancer tissues,adjencet cancer tissues,normal tissues of 30 esophageal patients by using in situ hybridization.Methods:Telomerase activity was detected by using in situ hybridization mRNA of telomerase.Results:28 of 30 exhibited telomerase activity in cancer tissues compared with 4/30 in adjencet cancer tissues ,0/30 in normal tissues,there is significant difference between them.( P <0.001).Conclusions:Telomerase detected by in situ is an accurate,efficient, sensitive and simple method.,there is significant to detected telomerase activity in situ for the early diagnosis of esophageal cancer. |
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| Keywords: | In Situ Hybridization Telomerase Activity Esophageal Cancer |
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