谷胱甘肽-S-转移酶基因多态与原发型肝癌的Meta分析

目的：探索谷胱甘肽-S-转移酶（GSTM1、GSTT1、GSTP1）基因多态与原发型肝癌遗传易患性的关系。方法：采用Meta分析方法对国内外1994--2004年关于谷胱甘肽-S-转移酶基因多态与原发型肝癌易患性的研究文献进行综合定量分析。结果：共收集相关文献18篇，累计病例1407例，对照2044例。GSTM1空白基因型可能与原发性肝癌有关，OR值为1．40（95％CI：1．22-1．62）；GSTM1和GSTT1中至少有一个空白基因型的OR值为2．05（95CI：％1．14-3．67），亦提示可能与原发型肝癌的遗传易患性有关；而GSTT1空白基因型、GSTP1突变基因型未显示与原发型肝癌相关，合并的OR值分别为1．13（95％CI：0．77-1．65）和0．68（95％CI：0．47～0．99）。结论：谷胱甘肽-S-转移酶基因多态与原发性肝癌遗传易患性的关系各有不同，GSTM1单项空白基因和GSTM1、GSTT1混合空白基因与原发性肝癌有统计学联系，可能是原发性肝癌的易患因素；GSTT1空白基因型与原发性肝癌未显示有统计学联系，而GSTP1的突变基因型可能是原发性肝癌的保护因素。

META- ANALYSIS ON THE RELATIONSHIP BETWEEN GLUTATHIONE S- TRANSFERASE GENETIC POLYMORPHISM AND SUSCEPTIBILITY TO PRIMARY LIVER CANCER

Objective:To study the association of genetic polymorphism of glutathione S-transferase(GSTM1,GSTT1,GSTP1) and their susceptibility to primary liver cancer.Methods: The results from 18 epidemiological studies on the relationship between glutathione S-transferase genetic polymorphism and susceptibility to primary liver cancer from 1994 to 2004 were analyzed synthetically by Meta-analysis.Results:A total of 1 407 cases and 2 044 controls from 18 studies was included.The results showed a relationship between GSTM1 null genotype and susceptibility to primary liver cancer,the pooled odds ratio(OR) values was 1.40(95%CI:1.22-1.62);the relationship also was found in the study on at least one null genotype in GSTM1 and GSTT1 OR=2.05(95%CI: 1.14-3.67).The null genotype of GSTT1 OR= 1.13(95%CI:0.77-1.65) and the mutated genotype of GSTP1 OR=0.68(95%CI:0.47-0.99) did not show a statistic relationship with susceptibility to primary liver cancer.Conclusion:Our results by Meta-analysis may support the positive associations of genetic polymorphism of glutathione S-transferase M1,M1 or T1 and susceptibility to primary liver cancer.None of the null genotype of GSTT1 and the mutated genotype of GSTP1 may be a risk factor of primary liver cancer.