Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine |
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| Authors: | Xiao Yangming Zhong Youmin Greene Whitney Dong Feng Zhong Guangming |
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| Institution: | Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229, USA. |
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| Abstract: | We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity. |
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