| 用免疫荧光试验观察恒河猴长期感染食蟹猴疟原虫的抗体消长 |
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| 引用本文： | 张家埙,林宝英,王良昌.用免疫荧光试验观察恒河猴长期感染食蟹猴疟原虫的抗体消长[J].现代免疫学,1984(1). |
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| 作者姓名： | 张家埙 林宝英 王良昌 |
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| 作者单位： | 中国医学科学院寄生虫病研究所
(张家埙，林宝英)，中国医学科学院寄生虫病研究所(王良昌) |
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| 摘 要： | 本文报告应用间接荧光抗体(IFA)试验,检测恒河猴感染了食蟹猴疟原虫后的抗体滴度,着重探讨长期感染的原虫密度和抗体滴度消长。结果表明,抗体滴度不仅在原虫密度高峰后较高,而且在红细胞内期低原虫密度阶段,甚至在原虫消失后4个多月内仍保持一定的水平。上述抗体滴度和原虫密度有规则的变化,对食蟹猴疟原虫-恒河猴模型的应用和间日疟的免疫研究提供了基础资料。
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IMMUNOFLUORESCENT ANTIBODY TITER IN RHESUS MONKEYS OF LONG-TERM INFECTION WITH PLASMODIUM CYNOMOLGI |
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| Abstract: | Antibody was detected with the indirect fluorescent antibody technique in rhesus monkeys infected with Plasmodium cynomolgi. The first peak of IFA titer occurred twenty three weeks after the monkeys infected by blood transmission or sporozoites inoculation and thereafter the titers varied slowly within a certain limited level, not only during the long infection course, but also about four months after the spontaneous clearance of parasitemia. The data obtained may be useful for further studies of immunity in tertain malaria. |
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