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Cardiac resurrection after bone-marrow-derived mononuclear cell transplantation during left ventricular assist device support |
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| Authors: | Gojo Satoshi Kyo Shunei Nishimura Shigeyuki Komiyama Nobuyuki Kawai Nobutaka Bessho Masami Sato Hiroshige Asakura Toshihisa Nishimura Motonobu Ikebuchi Kenji |
| Affiliation: | a Department of Cardiovascular Surgery, Saitama Medical Center, Saitama, Japan b Department of Cardiovascular Surgery, Saitama Medical School, Saitama, Japan c Department of Cardiology, Saitama Medical School, Saitama, Japan d Department of Hematology, Saitama Medical School, Saitama, Japan e Department of Transfusion and Cell Therapy, Saitama Medical School, Saitama, Japan |
| Abstract: | We describe a novel therapy of mononuclear cell transplantation combined with a left ventricular assist device (LVAD) for severe ischemic heart failure. Significant myocardial recovery by the LVAD rarely occurs in the severely failing heart. We undertook successful mononuclear cell transplantation in a patient who sustained an acute myocardial infarction that had resulted in the LVAD therapy. The heart regained good function after cell transplantation, and the LVAD was explanted 6 weeks later. These results suggest that this novel therapy could be an alternative to cardiac transplantation for severe ischemic heart failure. |
| Keywords: | 18/ 30 |
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