High-resolution chromosome painting reveals the first genetic signature for the chiropteran suborder Pteropodiformes (Mammalia: Chiroptera) |
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Authors: | Marianne Volleth Fengtang Yang Stefan Müller |
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Institution: | 1.Department of Human Genetics,Otto-von-Guericke-University,Magdeburg,Germany;2.The Wellcome Trust Sanger Institute,Wellcome Trust Genome Campus,Cambridge,UK;3.Institute of Human Genetics,University Hospital, Ludwig-Maximilians-University,Munich,Germany |
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Abstract: | Up to now, the composition of synteny-conserved segments in chiropteran karyotypes was studied by cross-species chromosome
painting with probes derived from whole human (HSA) or chiropteran chromosomes only. Here, painting probes from the vespertilionid
bat Myotis myotis were hybridized, for the first time, onto human metaphase chromosomes. The segmental composition of bat karyotypes was further
refined by cross-species painting with probes derived from flow-sorted chromosomes of Tupaia belangeri and Eulemur macaco—two species with highly rearranged karyotypes. The use of such probes has led to the generation of higher resolution maps
between human chromosomes 1, 3, 4, 5, 6, 11 and 15 and their counterparts in Vespertilionidae and the pteropodid species Eonycteris spelaea. Interestingly, the order of four sub-regions within the largest homologous segment delimited by human chromosome 4 painting
probe in Eonyceris was found to be different from that found in vespertilionids. A subsequent survey across all major chiropteran families demonstrated
that a paracentric inversion within this HSA 4 homologous segment could represent a synapomorphic character for the suborder
Pteropodiformes. |
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