干扰素α-2b联合三氧治疗慢性乙型肝炎效果

目的探讨干扰素(Interferon,IFN)α-2b联合三氧治疗慢性乙型病毒性肝炎(ChronichepatitisB,CHB)患者的临床疗效。方法将60例慢性乙型肝炎患者随机分为两组:对照组30例,接受干扰素α-2b治疗,500万U,肌肉注射,3次/周;治疗组患者30例,在使用干扰素α-2b治疗的同时,加用三氧自体血回输疗法,前12周3次/周,后10周2次/周。两组患者干扰素使用疗程均为24周。分别在治疗开始前、治疗12、24周以及治疗停药后24周观察CHB患者血清谷丙转氨酶(ALT)、HBeAg定量以及HBV-DNA水平的变化。结果干扰素α-2b联合三氧治疗组血清HBeAg阴转率、HBVDNA阴转率、完全应答率明显高于干扰素α-2b治疗组(P<0.05),ALT复常率两组无明显差异(P>0.05)。结论干扰素α-2b联合三氧治疗慢性乙型肝炎的疗效优于单用干扰素α-2b。

Clinical study of interferon α-2b combined with ozone therapy in the treatment of chronic hepatitis B

Objective To study the effect of interferon α-2b combined with ozone therapy in the treatment of chronic hepatitis B. Methods Sixty patients with chronic hepatitis B were divided into two groups. Thirty patients treated with interferon α-2b plus ozone therapy were taken as a treatment group. The other thirty patients receiving interferon α-2b therapy alone were as a control group. Their courses of treatment were all for 24 weeks. The percentage of HBeAg HBVDNA negativity, the normalized rates of ALT were studied at initial 12 weeks, 24 weeks and post-treatment 24 weeks. Results The percentage of HBeAg and HBVDNA negativity and the complete response rate of the group treated with interferon α-2b were significantly higher than the group treated with interferon α-2b combined with ozone therapy (P<0.05). The normalized rates of ALT showed no significant differences (P>0.05). Conclusion Compared with interferon α-2b alone, α-interferon combined with ozone therapy is more effective for treating patients with chronic hepatitis B.