5-氨基酮戊二酸光动力疗法治疗重症痤疮疗效评价

目的:评价5-氨基酮戊二酸光动力疗法(ALA-PDT)治疗重度痤疮的临床疗效。方法:36例重度痤疮患者随机分为治疗组和对照组(各18例)。治疗组给予ALA-PDT治疗,10天1次,共3次。对照组给予维胺酯50 mg口服,日3次和过氧苯甲酰凝胶外涂,每晚1次,共4周。结果:治疗组在第4、8和12周的有效率分别为50%、66.6%和83.3%;对照组有效率分别为22.2%、33.3%和27.8%,两组差异均有统计学意义(均P0.05)。结论:ALA-PDT是治疗重度痤疮的有效方法。

Assessment of ALA-PDT in the treatment of severe acne

Objective： To assess the therapeutic efficacy of photodynamic therapy （PDT） using topical 5-aminolevulinic acid （ALA） in the treatment of severe acne. Methods： Thirty six patients with refractory acne were divided into the treatment group and control group （18 patients in each group）. The treatment group was treated with photodynamic therapy with 5-aminolevulinic acid （ALA-PDT）, once every 10 days, for 3 times. The control group was treated with viaminate, 50 mg, 3 times a day and benzoyl peroxide, once a day, for 4 weeks. Results： The effective rates of ALA-PDT group were 50%, 66.6% and 83.3% at week 4, 8 and 12 week. The effective rates of control group were 22.2%, 33.3% and 27.8%. The differences between the two groups were significant （P〈0.05%）. Conclusion： ALA-PDT is effective in the treatment of severe acne.