胰岛素样生长因子结合蛋白7靶向治疗银屑病的研究进展

胰岛素样生长因子结合蛋白7(IGFBP7)属于胰岛素样生长因子结合蛋白超家族成员,参与细胞内信号转导、细胞生长及细胞代谢,在人类多种组织中均有表达。IGFBP7在银屑病患者表皮中表达显著降低,其参与银屑病发病的机制可能为通过胰岛素及IGFs等信号途径抑制角质形成细胞增殖、诱导其分化及凋亡,下调VEGF的表达从而抑制新生血管生成。维A酸类药物治疗银屑病取得较好疗效,可能与其直接或间接调节IGFs的活性,上调IGFBP7及其mRNA的表达相关。

Insulin-like growth factor-binding protein 7 as a potential therapeutic target to psoriasis

Insulin-like growth factor-binding protein 7 （ IGFBP7） a member of IGFBP superfamily involving in intracellular signaling cell growth and cell metabolism is expressed in a wide variety of human tissues. IGFBP7 expression is significantly reduced in psoriatic lesion. The role of IGFBP7 in the pathogenesis of psoriasis is the induction of cell differentiation and apoptosis alleviation of keratinocyte proliferation abnormalities and down-regulation of the VEGF expression to inhibit angiogenesis. Retinoids are acknowledged as effective drugs for psoriasis and the potential mechanism is related to the regulation of IGFs directly or indirectly and up-regulation of IGFBP7 mRNA and protein.