中国汉族人群精神分裂症与KPNB3基因多态性的关联分析

目的：探讨13q32区域亲核素β3（KPNB3）基因多态性与精神分裂症的关系。方法：采用PCR-RFLP方法，对中国北方汉族人群（精神分裂症患者382例和健康对照389例）13号染色体KPNB3基因上3个SNPs（rs626716、rs624066及rs2761072）进行等位基因及基因型检测。应用χ²检验分析各位点等位基因及基因型频数在两组中的分布差异。结果：KPNB3基因的3个SNPs rs626716、rs624066、rs2761072等位基因C、T在病例组和对照组中的频数分布比较，差异均无显著性（χ²=2.960， P> 0.05;χ²=1.119，P> 0.05; χ²=0.960，P>0.05)；在病例组和对照组中基因型C/C、C/T、T/T频数分布比较，差异也均无显著性(χ²=4.699，P>0.05;χ²=2.350，P>0.05;χ²=2.941，P>0.05）。结论：KPNB3基因可能不是精神分裂症的易感基因。

Association between KPNB3 gene polymorphism and schizophrenia in Chinese Han population

Objective To investigate the association between KPNB3 gene at 13q32 and schizophrenia.Methods The method of PCR-RFLP was conducted to examine the genotypes of KPNB3 gene in 382 patients with schizophrenia and 389 healthy Han people in the north of China.And then the frequencies of genotypes and alleles of KPNB3 gene were statistically computed.Results The χ2 goodness-fit test showed the genotypic distribution of three SNPs(rs626716,rs624066 and rs2761072) did not deviate from Hardy-Weinberg equilibrium either in the patient group or in the control group(P>0.05).There were no significantly differences of the allelic and genotypic frequency distributions of KPNB3 between the patients and the controls(P>0.05).Conclusion The KPNB3 gene may not be the susceptible locus of schizophrenia.