| 利培酮与氯氮平治疗精神分裂症的临床对照研究 |
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| 引用本文： | 郭慧荣,张绍荣,孙富根. 利培酮与氯氮平治疗精神分裂症的临床对照研究[J]. 新乡医学院学报, 2001, 18(3): 174-176 |
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| 作者姓名： | 郭慧荣 张绍荣 孙富根 |
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| 作者单位： | 新乡医学院第二附属医院, |
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| 摘 要： | 目的 探讨利培酮对精神分裂症的临床疗效和副作用。方法 对 6 3例精神分裂症患者应用利培酮 (32例 )和氯氮平 (31例 )进行对照研究。采用阳性症状与阴性症状量表(PANSS)、临床总体印象量表 (CGI)、副反应量表 (TESS)和临床疗效评定标准进行评估 ,分别评定疗效和副反应。结果 利培酮组与氯氮平组疗效近似 (P >0 .0 5 ) ;利培酮组与氯氮平组的显效率无显著性差异 (P >0 .0 5 )。利培酮组副反应较氯氮平组明显少且轻微。结论 利培酮与氯氮平对精神分裂症阳性阴性症状均有较好的疗效 ,但利培酮具有口服剂量小、投药方便、副作用小等优点
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| 关 键 词： | 利培酮 氯氮平 精神分裂症 |
| 文章编号： | 1004-7239(2001)03-0174-03 |
| 修稿时间： | 2001-04-20 |
Clinical controlled study of risperidone and clozapine in treatment of schizophrenia |
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| GUO Hui-rong,ZHANG Shao-rong,SUN Fu-gen. Clinical controlled study of risperidone and clozapine in treatment of schizophrenia[J]. Journal of Xinxiang Medical College, 2001, 18(3): 174-176 |
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| Authors: | GUO Hui-rong ZHANG Shao-rong SUN Fu-gen |
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| Abstract: | Objective To investigate the clinical efficacy and the side effects of risperidone in the treatment of schizophrenia.Method The schizophrenic patients in 32 cases were treated with risperidone and a control group of 31 patients treated with clozapine. Both groups were assessed with the PANSS and CGI, before and after treatment to evaluate the effects with positive and negative symptoms, and the side effects were evaluated with TESS.Results The therapeutic efficacy in risperidone group was similar to that in clozapine group(P>0.05). But the side effects of risperdone were lighter than that of clozapine.Conclusion The risperidone and clozapine are effective in the treatment of positive and negative symptoms of schizophrenia, but risperidone has the advantages of convenient administration with lower dosage and side effects. |
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| Keywords: | risperidone clozapine schizophrenia |
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