Anti-inflammatory,Antioxidant and Antimicrobial Effects of Artemisinin Extracts from Artemisia annua L. |
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| Authors: | Wan-Su Kim Woo Jin Choi Sunwoo Lee Woo Joong Kim Dong Chae Lee Uy Dong Sohn Hyoung-Shik Shin Wonyong Kim |
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| Institution: | 1Department of Periodontology, College of Dentistry, Wonkwang University, Iksan 570-749, Korea.;2Department of Microbiology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea.;3Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.;4Asia Pacific International School, Seoul 139-852, Korea.;5DOSIS M&M, Seoul 143-891, Korea. |
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| Abstract: | The anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of Artemisia annua L. were evaluated. All 4 artemisinin-containing extracts had anti-inflammatory effects. Of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (NO), prostaglandin E2 (PGE2), and proinflammatory cytokine (IL-1β , IL-6, and IL-10) production. Antioxidant activity evaluations revealed that the ethanol extract had the highest free radical scavenging activity, (91.0±3.2%), similar to α-tocopherol (99.9%). The extracts had antimicrobial activity against the periodontopathic microorganisms Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum subsp. animalis, Fusobacterium nucleatum subsp. polymorphum, and Prevotella intermedia. This study shows that Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases. |
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| Keywords: | Anti-inflammatory effect Anti-microbial activity Antioxidant activity Artemisinin |
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