赤芍、甘草等中药合剂治疗急性荨麻疹机理的实验研究

目的 赤芍、甘草等中药合剂(简称抗敏口服液)治疗急性荨麻疹的机理。方法 ①动物实验:肥大细胞脱颗粒实验,被动皮肤过敏实验;②实验室检测:双抗体夹心ELISA法检测急性荨麻疹患者治疗前后IL-2、IL-4水平。结果 抗敏口服液组肥大细胞脱颗粒百分数及吸光度值明显低于其它各组药物(P<0.01),抗敏口服液可使急性荨麻疹患者体内升高的IL-4及降低的IL-2恢复到正常。结论 抗敏口服液可稳定肥大细胞膜、抑制抗原抗体结合、调整IL-2和IL-4浓度,对急性荨麻疹有较好的治疗效果。

TherapeuticMechanism of A Chinese Medicine Decoction for Urticaria

Objective To investigate therapeutic mechanism of a Chinese medicine decoction for urticaria. Methods Mastocyte degranulation test and passive skin allergy test were conducted in animal model. A sandwich ELISA technique was applied to detect serum IL-2 and IL-4 in patients with acute urticaria before and after oral administration of the decoction. Results Significant inhibition of mastocyte degranulation was found in mice taken the decoction in comparison with controls. There were significantly increased level of IL-2 and reduced level of IL-4 in sera of patients with acute urticaria. Serum levels of IL-2 and IL-4 recovered to normal in patients after taking the decoction. Conclusion The Chinese medicine decoction appears to stabilize the membrane of mastocytes and inhibit antigen-antibody binding. The decoction is also likely to adjust serum levels of IL-2 and IL-4 to normal.