颅脑支架在颅脑损伤中的应用及其并发症：优劣分析

目的：探讨颅脑支架在治疗颅脑损伤的现状，以及颅脑支架的生物相容性及其置入引起的并发症情况。 方法：用计算机检索中国期刊全文数据库(CNKI：1988/2009)和Medline database(1988/2009)，按纳入和排除标准，对文献进行筛选，资料收集和质量评价，共纳入37篇文章。从颅脑支架在颅脑损伤中应用的现状、颅脑支架的生物相容性和由颅脑支架置入引起的并发症3方面进行总结。 结果：颅脑支架对于目前外科手术和药物治疗都较为棘手的颅脑血管病变也有较好疗效。颅脑支架的生物相容性，影响其置入人体后的安全性和有效性，生物相容性越差，引起并发症的机会就越大。颅脑支架置入后可能引起如血栓形成、脑出血、再狭窄以及高灌注、低灌注等各种并发症，应在支架置入后密切注意患者的状况。 结论：颅脑支架置入技术在颅脑损伤治疗中显示了较好的效果，但因其与人体的生物相容性问题，可能导致并发症的产生，对此神经介入医师值得注意。

Application and complication of cranial scaffold following craniocerebral injury: A contrast analysis

OBJECTIVE: To investigate the current situation of cranial scaffold for the treatment of craniocerebral injury, analyze biocompatibility of the cranial scaffold, and observe the cranial scaffold-induced complications. METHODS: A computer-based online search was conducted in CNKI and Medline database in accordance with inclusion and exclusion criteria from 1988 to 2009. A total of 37 articles were included in the final analysis, which were summarized based on application situation of cranial scaffold for the treatment of craniocerebral injury, biocompatibility of cranial scaffold, and cranial scaffold-induced complication. RESULTS: Cranial scaffold had a good effect on the treatment of craniocerebral injury which was hard to be treated using surgical intervention and drug therapy. The biocompatibility of cranial scaffold might influence its security and efficiency. The poor biocompatibility of cranial scaffold increased incidence of varying complications, including thrombosis, cerebral hemorrhage, restenosis, hypertransfusion, and hypoperfusion. Therefore, patients should be cared carefully following scaffold implantation. CONCLUSION: Cranial scaffold implantation has a good effect on the treatment of craniocerebral injury; however, its biocompatibility to human body may cause complications which attract much attention by physicians.