Effects of Lentinan on Cytotoxic Functions of Human Lymphocytes |
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| Authors: | Gergely P ater Vallent K aroly Bod
A Imre Feh Ar J anos Yutaro Kaneko |
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| Affiliation: | a Second Department of Medicine and First Department of Surgery, Semmelweis University, Budapest, Hungary, Pharmaceuticals and Development Department, Ajinomoto Co., Inc., Tokyo, Japan |
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| Abstract: | The in vitro effects of lentinan on natural killer (NK), antibody-dependent cell-mediated cytotoxicity (ADCC), lectin-dependent cell-mediated cytotoxicity (LDCC) and mitogen-induced blast transformation were studied in patients with solid tumors and chroyic lymphocytic leukemia (CLL). NK activity was measured against Cr-labelled K-562 targets, ADCC against antibody-coated chicken red cells. LDCC and natural cell-mediated cytotoxicity (NCMC) was assessed using 3H-thymidine prelabelled HEp-2 targets. Mitogen (PHA-and Con A-) induced blast transformation was measured by thymidine incorporation.
Blastogenesis and LDCC was not influenced by lentinan. 1 μg/ml lentinan increased NCMC of tumor-bearing subjects. The most prominent enhancement of NK and ADCC activity was seen in CLL patients, where a dose-related increase was seen (from 0.01 to 1 μg/ml). |
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