| 血小板激活因子拮抗剂YM-264对抗原引起气道嗜酸性粒细胞浸润的影响 |
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| 引用本文： | 谢正福,施焕中,覃寿明,许辉,陈一强,覃筱燕,李超乾. 血小板激活因子拮抗剂YM-264对抗原引起气道嗜酸性粒细胞浸润的影响[J]. 广西医科大学学报, 1997, 0(2) |
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| 作者姓名： | 谢正福 施焕中 覃寿明 许辉 陈一强 覃筱燕 李超乾 |
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| 作者单位： | 广西医科大学第一附属医院呼吸内科 |
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| 摘 要： | 应用鸡卵清蛋白致敏和刺激小鼠复制过敏性气道炎症反应模型研究血小板激活因子选择性拮抗剂ＹＭ－２６４对抗原引起气道嗜酸性粒细胞（ＥＯＳ）浸润的影响。结果发现，正常小鼠支气管肺泡灌洗液（ＢＡＬＦ）中未见到ＥＯＳ；致敏小鼠给予抗原多次反复吸入刺激后，ＢＡＬＦ中ＥＯＳ急剧增多。在ＹＭ－２６４治疗各组中，ＹＭ－２６４的不同剂量分别导致ＥＯＳ数下降２７．０％、４８．２％及６７．９％。还发现ＹＭ－２６４抑制ＥＯＳ对气道的浸润伴随着白细胞介素（ＩＬ）－５水平的明显下降。提示ＹＭ－２６４通过抑制ＩＬ－５的产生从而抑制了ＥＯＳ在气道的聚集。
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| 关 键 词： | 血小板激活因子；白细胞介素－5；哮喘；趋化因子 |
EFFECTS OF A PLATELET ACTIVATING FACTOR ANTAGONIST YM 264 ON ANTGEN INDU CED EOSINPHIL INFILTRATION OF THE AIRWAYS |
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| Xie Zhengfu,Shi Huanzhong,Qing Shouming,et al. EFFECTS OF A PLATELET ACTIVATING FACTOR ANTAGONIST YM 264 ON ANTGEN INDU CED EOSINPHIL INFILTRATION OF THE AIRWAYS[J]. Journal of Guangxi Medical University, 1997, 0(2) |
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| Authors: | Xie Zhengfu Shi Huanzhong Qing Shouming et al |
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| Abstract: | An in vivo mouse model of allergic bronchial inflammation was developed to investigate the effects of a platelet activatign factor antagonist YM 264 on the eosinphils(EOS) infiltration of the airways.EOS were not found in the bronchoalveolar lavage fluid (BALF) obtained from normal contol mice.However,EOS appeared in BALF and increased rapidly in ovalbumin sensitized mice.Different doses of YM 264 induced respectively 27 0%,48 2%and 67 9% decrease of the antigen induced influx of EOS into BALF.Also,the prevention of EOS infiltration into the airways by YM 264 was acommpanied by a decrease in the interleukin (IL) 5 levels.These data indicated that YM 264 prevented airway eosinphilia by inhibiting the production of IL 5. |
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| Keywords: | platelet activating factor interleukin 5 asthma chemotactic factors |
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