灵芝颗粒对2型糖尿病患者胰岛素敏感性及氧化应激的干预作用

目的:观察灵芝颗粒对2型糖尿病患者糖代谢、胰岛素敏感性及氧化应激水平的影响。方法:选择2型糖尿病患者75例,随机分为中药组及对照组两组。中药组47例在常规治疗基础上加用灵芝颗粒,对照组28例在常规治疗基础上加用安慰剂颗粒。治疗8周后,观察并比较两者血糖、糖化血清白蛋白、胰岛素、C肽、胰岛素抵抗指数(HOMAIR)、超氧化物歧化酶(Superoxide Dismutase,SOD)及丙二醛(malondialdehyde,MDA)的变化。结果:中药组患者治疗后餐后血糖、糖化血清白蛋白、HOMA-IR、SOD及MDA均有明显下降,且治疗后中药组餐后血糖、HOMA指数及MDA指标改善情况显著优于对照组。结论:灵芝颗粒能有效改善2糖尿病患者的糖代谢及胰岛素敏感性,并同时改善患者氧化应激水平。

Effect of Lingzhi Herb Granule on Insulin Sensitivity and Oxidative Stress of Patients with Type 2 Diabetes

Objective: To observe the effect of Lingzhi Herb Granule on glucose metabolism,insulin sensitivity and oxidative stress of patients with type 2 diabetes. Methods: 75 type 2 diabetes patients were randomly divided into Chinese herb group( receive conventional treatment and Lingzhi Herb Granule,n = 47) and control group( received conventional treatment and placebo granule,n = 28). After 8 weeks treatment,the pre-and post-treatment changes in blood glucose,glycated albumin,insulin,C-peptide,insulin resistance index( HOMA-IR),superoxide dismutase( SOD) and malondialdehyde( MDA) were compared. Results: After treatment,postprandial blood glucose,glycated albumin,HOMA-IR,SOD and MDA of Chinese herb group had obviously decreased. The treatment group also showed a greater reduction of postprandial blood glucose,HOMA-IR and MDA compared to those of the control group. Conclusion: Lingzhi Herb Granule can effectively ameliorate the glucose metabolism,insulin sensitivity and the oxidative stress level of type 2 diabetes.