孕妇清火丸口服和肤舒止痒膏外洗治疗妊娠期肝内胆汁淤积症30例

目的:探讨口服孕妇清火丸和肤舒止痒膏外洗在妊娠期肝内胆汁淤积症治疗中的临床应用。方法:选取ICP患者60例,将其随机分为治疗组与对照组,每组30例。其中对照组给予思美泰静脉滴注治疗,治疗组给予口服孕妇清火丸和肤舒止痒膏外洗联合应用治疗,疗程为14 d。观察并比较两组患者瘙痒症状改善情况、孕周、肝功能指标的改善情况及妊娠结局等,并观察两组患者的不良反应。结果:两组患者治疗后,皮肤瘙痒症状出现明显好转,与治疗前比较,差异具有统计学意义(P<0.05);治疗后,治疗组患者瘙痒症状评分较对照组低,差异有统计学意义(P<0.05);治疗后,治疗组患者孕周为(37.1±0.12)周,与对照组患者(34.3±0.19)周比较,差异有统计学意义(P<0.05);治疗后,两组患者的总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)及胆汁酸(TBA)水平都明显降低,与治疗前比较,差异有统计学意义(P<0.05);并且与对照组比较,治疗组治疗后TBIL、ALT及TBA水平下降更显著,有统计学意义(P<0.05);对照组在治疗过程中出现恶心、头痛、面色潮红等不良反应,而治疗组无不良反应发生。结论:口服孕妇清火丸和肤舒止痒膏外洗治疗妊娠期肝内胆汁淤积症具有明显的治疗效果,同时无明显的不良反应发生,值得在临床上大力的推广与应用。

Yunfu Qinghuo Wan and Fushu Zhiyang Gao in Treatment of 30 Cases of Intrahepatic Cholestasis Disease during Pregnancy

Objective: To explore the clinical application of Yunfu Qinghuo Wan and Fushu Zhiyang Gao in the treatment of intrahepatic cholestasis disease during pregnancy. Methods: 60 cases with ICP in our hospital for treatment at the time from September 2013 to August 2014 were divided into treatment group and control group with 30 cases in each randomly. The control group was given intravenous drip treatment and the treatment group given Yunfu Qinghuo Wan and Fushu Zhiyang Gao,treatment for 14 days. We observed and compared the improvement of the itching,gestational age,index of liver function and pregnancy outcomes between the two groups and observed the adverse reactions in the two groups. Results: Compared with before treatment,the itchy skin improved significantly after treatment and the difference was statistically significant( P < 0. 05). After treatment,the score of the itching of the treatment group was lower than that of the control group. The gestational age of the treatment group was 37. 1 ±0. 12 weeks and compared to the 34. 3 ± 0. 19 weeks of the control group,the difference was statistically significant( P < 0. 05).The total bilirubin( TBIL),alanine aminotransferase( ALT) and bile acid( associates) levels were significantly decreased and compared with those before treatment,the difference was statistically significant( P < 0. 05). And compared with control group,the levels of TBIL,ALT and associates of the treatment group decreased more significantly( P < 0. 05). During the treatment,there were several adverse reactions such as nausea,headache or pale flush appeared in the control group,but it didn't appear in the treatment group. Conclusion: The treatment of Yunfu Qinghuo Wan and Fushu Zhiyang Gao for intrahepatic cholestasis disease during pregnancy has obvious therapeutic effect and no adverse reactions at the same time. It is worthy of popularization and application widely in clinical application.