| 摘 要： | AIM:An investigation into inflammatory bowel disease andcolorectal cancer in Veszprem Province was conducted from1977 to 2001,METHODS:Both hospital and outpatient records werecollected and reviewed comprehensively.The majority ofpatients were followed up regularly.RESULTS:The population of the province was decreasedfrom 386 000 to 376 000 during the period.Five hundredsixty new cases of ulcerative colitis (UC),212 of Crohn'sdisease (CD),and 40 of indeterminate colitis (IC) werediagnosed.The incidence rates increased from 1.66 to 11.01cases per 100 000 persons for UC,from 0.41 to 4.68 for CDand from 0.26 to 0.74 for IC.The prevalence rate at the endof 2001 was 142.6 for UC and 52.9 cases per 100 000 personsfor CD.The peak onset age in UC patients was between 30and 40 years,in CD between 20 and 30 years.A familyhistory of IBD was present in 3.4% in UC and 9.9% in CDpatients.Smoking increased the risk for CD (OR=1.94) whileit decreased the risk for UC (OR=0.25).Twelve colorectalcarcinomas were observed in this cohort,the cumulativecolorectal cancer risk after 10 years in UC was 2%,after20 years 8.8%,after 30 years 13.3%.CONCLUSION:The incidence and prevalence rates of IBDhave increased steadily in Veszprem Province,now equivalentto that in Western European countries.Rapid increase inincidence rates supports a probable role for environmentalfactors.The rate of colorectal cancers in IBD is similar tothat observed in Western countries.
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