| 荔枝核黄酮类化合物体外抗呼吸道合胞病毒的作用 |
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| 引用本文： | 梁荣感,刘卫兵,唐祖年,徐庆. 荔枝核黄酮类化合物体外抗呼吸道合胞病毒的作用[J]. 医学争鸣, 2006, 27(20): 1881-1883 |
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| 作者姓名： | 梁荣感 刘卫兵 唐祖年 徐庆 |
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| 作者单位： | 桂林医学院药理学教研室,广西,桂林,541004;广西师范大学化学化工学院,广西,桂林,541004 |
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| 基金项目： | 广西世行贷款/国外赠款中国传染性非典型肺炎及其他传染病应对项目 |
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| 摘 要： | 目的: 探讨荔枝核黄酮类化合物体外抗呼吸道合胞病毒(RSV)的作用. 方法: 采用细胞培养技术,以病毒唑为阳性对照,观察比较荔枝核黄酮类化合物对RSV引起的细胞病变(CPE)的抑制作用. 结果: 荔枝核黄酮类化合物半数中毒浓度(TC50)为152.9 mg/L,其抗RSV的半数有效浓度(IC50)为58.6 mg/L,治疗指数(TI)为2.6,体外抗RSV作用与病毒唑相当,且对RSV抑制作用存在明显的量效关系. 结论: 荔枝核黄酮类化合物在Hep-2细胞中对呼吸道合胞病毒有抑制作用.
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| 关 键 词： | 荔枝核 黄酮类 呼吸道合胞病毒 抗病毒作用 |
| 文章编号： | 1000-2790(2006)20-1881-03 |
| 收稿时间： | 2005-09-14 |
| 修稿时间： | 2006-03-23 |
Inhibition on respiratory syncytial virus in vitro by flavonoids extracted from the core of Litchi Chinensis |
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| LIANG Rong-Gan,LIU Wei-Bing,TANG Zu-Nian,XU Qing. Inhibition on respiratory syncytial virus in vitro by flavonoids extracted from the core of Litchi Chinensis[J]. Negative, 2006, 27(20): 1881-1883 |
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| Authors: | LIANG Rong-Gan LIU Wei-Bing TANG Zu-Nian XU Qing |
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| Affiliation: | 1.Department of Pharmacology, Guilin Medical College, 2.College of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin 541004, China |
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| Abstract: | AIM: To evaluate the anti-respiratory syncytial virus (RSV) effect of flavonoids extracted from the core of Litchi Chinensis in cell culture in vitro. METHODS: By the method of cell culture and using ribavirin as a positive control, the cytopathic effect(CPE) was observed. RESULTS: The TC50 and IC50 of the flavonoids extracted from the core of Litchi Chinensis was 152.9 mg/L and 58.6 mg/L respectively. The therapeutic index (TI) was 2.6, It had the same effect as Ribavirin in anti-RSV. Moreover, flavonoids extracted from the core of Litchi Chinensis also showed a concentration-dependent response in inhibiting RSV. CONCLUSION: Flavonoids extracted from the core of Litchi Chinensis can inhibit RSV in Hep-2 cells in vitro. |
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| Keywords: | semen litchi Flavones respiratory syncytial viruses (RSV) antiviral effect |
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