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THE VALUE OF ISOTYPE DETERMINATION OF SERUM ANTIBODIES AGAINST CHLAMYDIA FOR THE DIAGNOSIS OF CHLAMYDIA REACTIVE ARTHRITIS |
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| Authors: | BAS S; CUNNINGHAM T; KVIEN T K; GIENNAS A; MELBY K; VISCHER T L |
| Institution: |  Department of Microbiology, Ullevàl University Hospital Oslo, Norway*Oslo City Department of Rheumatology, Norwegian Lutheran Hospital Oslo Division of Rheumatology, University Hospital Geneva, Switzerland |
| Abstract: | In clinical rheumatology, the diagnosis of Chlamydia reactivearthritis is difficult because an incomplete form of the diseasecan closely resemble an undifferentiated seronegative mono/oligoarthritis.We investigated whether measuring specific isotypes of anti-Chlamydiaantibodies in serum can improve the diagnosis, by comparingsuch antibody concentrations in the serum of patients with well-defineddisease, i.e. Chlamydia trachomatis sexually acquired reactivearthritis (CT-SARA), with other arthritides. Antibody levelswere determined by enzyme-linked immunosorbent assay (ELISA).When considering two different isotypes and their combination,the best sensitivity (63%) was obtained for IgM and/or IgA resultswith a specificity of 81%. The patients with CT-SARA and SARAhad the highest levels of antibodies of all isotypes tested.It is concluded that, in our experimental conditions, only veryhigh values of specific isotypes could indicate a diagnosisof Chlamydia reactive arthritis. KEY WORDS: Sexually acquired reactive arthritis, Chlamydia, Antibodies, Enzyme-linked immunoassay |
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