Expression of pepsinogen I and II in human gastric carcinoma and precarcinous lesion

The antibodies to PgI and PgII are used to do the immunohistochemical study in human gastric carcinoma and precarcinous lesion. The results show that in embryo gastric mucosa the expression of PgI is positive while PgII is negative; in normal gastric mucosa both Pgs are positive expression; In precarcinous lesion of stomach the positive rate of both Pgs decrease strikingly, and decrease further to the lowest level when the gastric cancer occurs. It is suggested that PgI and PgII are the special marker of normal gastric mucosa. There is no obvious difference of PgI and PgII in the various types of gastric carcinoma. Both Pgs levels in advanced gastric cancer are higher than that in early stage. PgII expression is more in gastric cancer accompanied by lymphatic metastasis, which may be beneficial to the estimate of gastric carcinoma prognosis.