Antiplasmodial sesquiterpene alkaloids from the roots of Maytenus mekongensis |
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Authors: | Lhinhatrakool Thitima Prabpai Samran Kongsaeree Palangpon Sutthivaiyakit Somyote |
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Institution: | Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Hua Mark, Bangkapi, Bangkok 10240, Thailand. |
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Abstract: | Eight new sesquiterpene alkaloids (1-8) and four known sesquiterpene alkaloids (9-12) have been isolated from the roots of Maytenus mekongensis. Structures were determined using extensive spectroscopic methods. The relative configuration of 7-epi-mekongensine (2) was established by single-crystal X-ray crystallographic analysis. The alkaloids were evaluated for antiplasmodial activity against Plasmodium falciparum, K1 strain, and for cytotoxicity using a panel of cell lines. |
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