Effects of histamine-receptor antagonists on histamine-stimulated renin secretion |
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Authors: | K J Radke L R Willis G W Zimmerman M H Weinberger E E Selkurt |
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Affiliation: | 1. Division of Nephrology and Multi-Organ Transplant Program, McGill University Health Centre, 1001 boul. Decarie, Montreal, QC, Canada. H4A 3J1;2. Michigan State University College of Osteopathic Medicine, East Fee Hall, 965 Fee Rd, East Lansing, MI 48825, USA |
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Abstract: | The effects of histamine H1- and H2-receptor antagonists on histamine-stimulated renin secretion were examined in anesthetized dogs. Tripelennamine (H1 blocker) further enhanced renin secretion in the presence of exogenous histamine. Moreover, tripelennamine alone increased renin secretion. These effects are probably due to non-specific properties of the drug and not to interaction of tripelennamine with H1 receptors. Conversely, cimetidine (H2 blocker) significantly inhibited histamine-induced increases in renin secretion, renal blood flow, and sodium excretion without any changes in mean arterial blood pressure or glomerular filtration rate. Cimetidine alone had no effect. We conclude that H2 receptors mediate the effect of histamine on renin secretion in dogs with innervated, intact kidneys. |
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