| Per1与Per2基因在胆管癌中的表达 |
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| 引用本文： | 荆波,杨福全,马锐.Per1与Per2基因在胆管癌中的表达[J].航空航天医学杂志,2016(9):1074-1077. |
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| 作者姓名： | 荆波 杨福全 马锐 |
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| 作者单位： | 1. 沈阳煤业集团总医院,辽宁沈阳,110122;2. 中国医科大学附属盛京医院胆道 疝 减肥外科,辽宁沈阳,110004;3. 沈阳军区总医院普外科,辽宁沈阳,110004 |
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| 摘 要： | 目的：分析人类生物钟基因Per1与Per2在人类胆管癌中的表达，研究其表达与人类胆管癌的关系。方法获取人原发胆管癌标本58份，另取距离肿瘤边缘2 cm外组织作为正常对照。采用免疫组织化学方法检测人原发胆管癌标本与正常对照组织中Per1与Per2基因蛋白产物（ Per1、Per2蛋白）的表达。结果58份人原发胆管癌标本与正常对照组织中均见Per 1与Per2蛋白表达，但胆管癌标本中Per1与Per2蛋白的表达较正常对照组织明显下降（ P＜0.05）。结论生物钟基因Per1与Per2蛋白可能与人类胆管癌的发生及发展有关。
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| 关 键 词： | Per1基因 Per2基因 胆管癌 免疫组织化学 |
Per1 and Per2 Gene Expression in CCA |
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| Abstract: | Objective To explore the human circadian clock gene (Per1 and Per2) protein expression in cholangio-carcinoma( CCA) ,and to study the relationship of the expression with CCA.Methods The Per1 and Per2 gene protein expression in CCA and the corresponding adjacent tissues obtained from 58 patients were detected by immunohistochemis-try.Results Per1 and Per2 protein expresses in both CCA and the corresponding adjacent tissues of 58 patients but the decreased expression in CCA patients compared to the corresponding adjacent tissues ( P<0.05 ).Co nclu sions Per1 and Per2 gene may be related to the incidence and development of CCA. |
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| Keywords: | Per1 gene Per2 gene Cholangiocarcinoma( CCA) Immunohistochemistry |
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