网素（L－plastin）在子宫内膜癌中的表达及意义

目的：探讨L－plastin在子宫内膜癌组织中的表达及其在癌变发生发展中的作用。方法采用免疫组织化学方法（ S－P法），检测45例子宫内膜癌、20例子宫内膜不典型增生，16例正常子宫内膜中的L－plastin的表达。观察其在子宫内膜癌临床病理学参数的关系，分析其在肿瘤发生发展中的作用。结果在子宫内膜癌中L－plastin蛋白的表达明显低于非典型增生内膜及正常增生期内膜组织（ P＜0.01）。在不同手术病理分期子宫内膜癌组织中有显著性差异（ P＜0.05），在不同病理分级的子宫内膜癌组织中无显著性差异（P＞0.05），在不同肌层浸润深度中有显著性差异（P＜0.05），在有无淋巴结转移子宫内膜癌组织中无显著差异（P＞0.05）。结论L－plastin蛋白参与了子宫内膜癌癌变的病理过程.L－plastin蛋白在子宫内膜癌中存在过度表达，L－plastin的过度表达与手术病理分期和肌层浸润深度有关。

Expression and Correlation of L-plastin in Endometrial Careinoma

Objective To evaluate the expression of L-plastin in endometrial careinoma and effect on the progress of careinoma.Methods The expression of L-plastin were examined in 45 cases of endometrial carcinoma,20 cases of atypical hyperplasia,and 16 cases of normal proliferatie phase of endometrium by the immunohistochemical method ( S-P method).Results The expression of L-plastin protein in endometrial carcinoma tissue,atypical hyperplasia endome-trium tissue and normal endometrium tissue.In endometrial carcinoma ,the expression of L-plastin was related to surgi-cal-pathological staging(P<0.05), but was related to histological grading(P>0.05);was related to myometrial inva-sion(P<0.05);but was related to nodus lymphaticus metachoresis(P>0.05).Conclusions L-plastin protein was involved in the pathological process of endometrial carcinoma.L-plastin protein were positive expressed in endometrial carcinoma tissue,and the positive expression of L-plastin protein was correlated to operation pathological staging and myometrial invasion.