| 血清甲胎蛋白阴性或低值大肝癌组织病理学和免疫组化观察 |
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| 引用本文： | 吴绮明 胡明华 等. 血清甲胎蛋白阴性或低值大肝癌组织病理学和免疫组化观察[J]. 江西医学院学报, 1996, 36(2): 7-9,F002 |
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| 作者姓名： | 吴绮明 胡明华 等 |
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| 作者单位： | 病理解剖学教研室，南昌330006 |
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| 基金项目： | 国家自然科学基金资助课题 |
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| 摘 要： | 观察了30例血清甲胎蛋白阴性或低值大肝癌的组织病理学和免疫组化学。发现有19例透明细胞型肝细胞癌，其中仅2例免疫组化试验甲胎蛋白阳性，此结果提示在肝细胞癌细胞内发生的透明变可抑制甲胎蛋白合成，这可能是导致大肝癌患者血清甲胎蛋白阴性或低值的因素之一。
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| 关 键 词： | 肝细胞瘤 病理学 免疫化学 组织细胞化学 甲胎蛋白类 |
Histopathology and Immunohistochemistry of Large HCC with Negative or Low Level Serum AFP |
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| Wu Qiming, Hu Minghua, Tan Yunshan. Histopathology and Immunohistochemistry of Large HCC with Negative or Low Level Serum AFP[J]. Acta Academiae Medicinae Jiangxi, 1996, 36(2): 7-9,F002 |
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| Authors: | Wu Qiming Hu Minghua Tan Yunshan |
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| Abstract: | Histopathology and immunohistochemistry of 30 cases of large hepatocellular carcinoma(LHCC)with serum alpha fetoprotein(AFP)negative or low level were observed.It wasfound that there were 19 cases(19/30)of clear cell type HCC,of which AFP was present inonly 2 cases examined immunohistochemically. The result suggests that clear changes withinHCC cells may inhibit synthesis of AFP in these cells.This might be one of the factors caus-ing negative or low level serum AFP in patients with LHCC. |
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| Keywords: | hepatoma/pathology histocytochemistry immunochemistry alpha fetoproteins |
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