雷罗昔芬治疗卵巢切除大鼠的实验研究

为探讨选择性雌激素受体调节剂雷罗昔芬(Raloxifene)对卵巢切除大鼠的骨密度、骨代谢、血脂代谢的影响，观测了Raloxifene治疗的卵巢切除大鼠腰椎和股骨骨密度、血清BGP、尿PYD、血清CHOL、TG、HDL、LDL、雌二醇(E2)、动脉钙磷含量等指标。结果表明，Raloxifene治疗卵巢切除大鼠后其E2增高，股骨和腰椎骨密度增高，骨转换降低，血清胆固醇和低密度脂蛋白胆固醇降低，而血清甘油三脂和高密度脂蛋白胆固醇无明显变化。结果提示，Raloxifene能提高卵巢切除大鼠骨密度，降低骨转换，保护脂代谢，提高雌激素水平，可能与其拟雌激素样作用有关。

Effects of Raloxifene on Ovariectomized Osteoporotic Rats

To observe the effects of Raloxifene on bone mineral density, bone metabolism and lipid metabolism of ovariectomized rats. We detected the BMD of spine and total hip, serum estrogen, serum lipid, markers of bone turnover, Ca, P content in artery wall in OVX rats administered by Raloxifene . Result shows that the BMD of OVX rat treated with Raloxifene increased on the spine and total hip, the level of estrogen (E2) increased significantly, markers of bone formation (serum BGP) and resorption (urinary PYD) decreased significantly, in addition, total serum cholesterol as well as LDL-cholesterol decreased significantly, and serum HDL-cholesterol and triglycerides did not significantly changed. So the Raloxifene could protect metabolism of bone and lipid, possibly due to its estrogen-like effect.