| 人脑动静脉畸形中VEGF的表达变化 |
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| 引用本文： | 卞留贯,孙青芳,王建,赵卫国,沈建康,丁美修,张天锡. 人脑动静脉畸形中VEGF的表达变化[J]. 脑与神经疾病杂志, 2002, 10(5): 285-286,284 |
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| 作者姓名： | 卞留贯 孙青芳 王建 赵卫国 沈建康 丁美修 张天锡 |
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| 作者单位： | 200025,上海第二医科大学瑞金医院神经外科 |
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| 摘 要： | 目的 :探讨 VEGF在脑动静脉畸形的变化。方法 :14例 AVMs行显微外科手术切除 AVMs和 AVMs周围脑组织、 8例正常脑血管和脑组织标本 ,分别提取总 RNA。 RNA狭逢斑点杂交检测 VEGF在脑 AVMs中的改变。结果 :与正常脑血管相比 ,AVMs、 AVMs周围脑组织 VEGF m RNA表达增高 ;结论 :VEGF可能与脑 AVMs的发生发展有关。
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| 关 键 词： | 血管内皮生长因子(VEGF) 脑动静脉畸形 |
| 文章编号： | 1006-351X(2002)05-0285-02 |
The relationship between VEGF and cerebral AVMs. |
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| Bian LG,SUN QF,Wang J et al. The relationship between VEGF and cerebral AVMs.[J]. Journal of Brain and Nervous Diseases, 2002, 10(5): 285-286,284 |
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| Authors: | Bian LG SUN QF Wang J et al |
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| Affiliation: | Bian LG,SUN QF,Wang J et alDepartment of Neurosurgery Shanghai Ruijin Hospital 200025 |
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| Abstract: | Objective: To explore the relationship between VEGF and cerebral AVMs. Methods: Total RNA was abstracted from 14 samples of AVMs brain tissue adjacent to AVMs, which were removed by microneurosurgery, and 8 cases of normal cerebral vessels and brain tissue. VEGF were detected by RNA slotblot. Results: upregulation of VEGF mRNA. Conclusion: VEGF might take part in the pathogenesis of cerebral AVMs development and growth. |
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| Keywords: | VEGF Cerebral AVMs |
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