| 认知储备与临床痴呆的研究进展 |
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| 引用本文： | 潘元青,梁海乾. 认知储备与临床痴呆的研究进展[J]. 国外医学:老年医学分册, 2011, 32(2): 80-86 |
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| 作者姓名： | 潘元青 梁海乾 |
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| 作者单位： | 潘元青,Pan Yuanqing(兰州大学基础医学院,兰州,730000,中国);梁海乾,Lang Haiqian(天津武警医学院附属一院,天津,300162,中国) |
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| 摘 要： | 认知储备是一种能力假设,即在成年人的大脑足以引起临床痴呆的病损时维持最优化的一种能力。个体的教育程度、职业、智力、健康等都能反映其认知储备能力。认知储备假设预测具有较高的认知能力将降低痴呆症的罹患风险因素,这些因素包括对成人认知能力的重要影响如饮食均衡、提供高品质的教育、职业的复杂性、稳定的社会关系及炎症反应、氧化应激、细胞凋亡及认知老化的神经病理。从这些方面看,认知储备对临床老化的影响可以理解为多个积极和消极的因素对老化认知功能保留的净结果。
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| 关 键 词： | 认知储备 临床痴呆 认知能力 |
Progress in Cognitive Reserve and Clinical Dementia |
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| Pan Yuanqing,Lang Haiqian. Progress in Cognitive Reserve and Clinical Dementia[J]. Foreign Medical Sciences(Geriatrics), 2011, 32(2): 80-86 |
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| Authors: | Pan Yuanqing Lang Haiqian |
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| Affiliation: | Pan Yuanqing Lang Haiqian( School of Basic Mcdical Science Affiliated to Lanzhou University, l,anzhou 730000 2The Hospital Affiliated to Tianjin Academiae CPAFI,, Tianjin 300160, China) |
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| Abstract: | Cognitive reserve is a hypothesized capacity of the mature adult brain to sustain the maximize performance of disease or injury sufficient to cause elinical dementia. Edueation, occupation, intelligence, health and so on can be used to measure the cognitive reserve. The hypothesis predicts that faclors associated with higher cognitive ability will also appear to lower the risk of dementia. These latter faetors inelude hnporlant influences on aduh cognitive ability, for example a balanced diel, oecupatlonal complexity, inflammation, a stable social relationship, oxidative stress, apoptosis and neuropathology of （ognitive ageing. Seen in these terms, impact from cognitive reserve on elinical dementia ean be understood as the net outcome of muhiple positive and negative determinants of retention. |
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| Keywords: | Cognitive reserve Clinical dementia Cognitive ability |
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