组织工程在视网膜退行性疾病中的应用进展

视网膜退行性疾病的主要病理基础是视网膜各级神经元的结构和功能性异常，最终造成患者视力的不可逆性损害，目前缺乏有效的治疗方法。近年来干细胞替代治疗方法的出现为此类致盲性眼病的治疗带来了希望，其相关研究已取得一定的进展。但是在研究中发现，干细胞的眼部移植仍存在着一些难点，如移植后细胞的移行能力、存活效率以及向目的细胞的分化能力等。因此，最近研究显示，视网膜组织工程技术的研究和发展有助于解决或弥补以上问题。针对目前干细胞和组织工程视网膜的研究状况，对视网膜组织工程的种子细胞、支架材料、体内移植技术等研究进展、取得的成绩和存在的问题进行综述。

Research advance in application of tissue engineering in degenerative retinal diseases

The pathogenic basis of degenerative retinal diseases is structural and functional abnormality of neuron of retina.The irreversible damage of visual function is the unfortunate results of degenerative retinal diseases,and some effective treating approach to these blindness eye diseases is still in expectation.In recent years,stem cells replacement therapy is increasingly developed and is a prospective way for degenerative retinal diseases.But some formidable challenges for successfully grafting cells to the retina are waiting for further solving,such as migration,survival,and differentiation of the stem cells etc.Recent studies showed that retinal tissue engineering technique may be a good alternation to address all the problems mentioned above.The current advances in stem cell and tissue engineering retina researches,including selectable seed cells,appropriate scaffold materials and transferring method in vivo,are reviewed in this paper.