| 2-取代-1-正丁基-5-苯基-3-吡唑烷酮类化合物抗惊厥作用的研究 |
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| 引用本文： | 全哲山,李海兰,朴虎日,赵立明,尹秀梅. 2-取代-1-正丁基-5-苯基-3-吡唑烷酮类化合物抗惊厥作用的研究[J]. 延边医学院学报, 1998, 0(4) |
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| 作者姓名： | 全哲山 李海兰 朴虎日 赵立明 尹秀梅 |
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| 作者单位： | 延边大学药学院 |
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| 摘 要： | 研究了５个２取代１正丁基５苯基３吡唑烷酮类化合物的抗惊厥作用．药理实验结果表明，５个化合物均有较好的抗惊厥活性，其中２肉桂酰基１正丁基５苯基３吡唑烷酮的抗惊厥作用最强，最大电惊厥半数有效剂量为１０．７ｍｇ／ｋｇ．
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| 关 键 词： | 3-吡唑烷酮类；惊厥；小鼠 |
Anticonvulsant activity of 2 substituted 1 n butyl 5 phenyl 3 pyrazolidinones |
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| Quan Zheshan,Li Hailan,Piao Huri,Zhao Liming,Yin Xiumei Yanbian University College of Pharmacy. Anticonvulsant activity of 2 substituted 1 n butyl 5 phenyl 3 pyrazolidinones[J]. Journal of Medical Science Yanbian University, 1998, 0(4) |
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| Authors: | Quan Zheshan Li Hailan Piao Huri Zhao Liming Yin Xiumei Yanbian University College of Pharmacy |
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| Abstract: | The anticonvulsant activity of five 2 substituted 1 n butyl 5 phenyl 3 pyrazolidinones was studied.The pharmacological experiment showed that they were all potent in activity. Among them 2 cinnamyl 1 n butyl 5 phenyl 3 pyrazolidinones was shown to be the most potent, and its maximal electroshock seizure ED 50 is 10.7mg/kg. |
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| Keywords: | pyrazolidinones convulsions mice |
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