代谢综合征及其代谢指标异常对患者血浆vWF与NO含量的影响

目的：观测代谢综合征（MS）患者血浆中血管性假性血友病因子（vWF）和一氧化氮（NO）含量的改变，探讨其对内皮功能的影响。方法：79例患者按MS代谢指标异常数量的不同分为1～2个代谢指标异常组（n=43）和MS组（n=36），另设正常对照组（n=30），测定其血浆中vWF及NO含量，分析MS代谢指标异常与vWF、NO的关系。结果：MS患者的vWF含量高于1～2个代谢指标异常组（P〈0．05）和正常对照组（P〈0．01），1～2个代谢指标异常组的vWF值高于正常对照组（P〈0．05）；MS组的NO含量低于正常对照组（P〈0．05），1～2个代谢指标异常组的NO含量低于正常对照组（P〈0．05），MS组与1～2个代谢指标异常组无明显差异（P〉0．05），但是在两组去除糖尿病患者后，MS组的NO值低于1～2个代谢指标异常组。结论：随着代谢指标异常增多，患者内皮功能受损加重。

Plasma levels of vWF and NO in patients with metabolic syndrome and their relationship with metabolic disorders

OBJECTIVE: To measure the plasma levels of von Willebrand factor (vWF) and nitric oxide (NO) in patients with metabolic disorders and to study their relationships with the disease. METHODS: The plasma levels of vWF and NO were determined in patients with metabolic syndrome (MS group, n=36), patients with 1 - 2 metabolic disorders (MD group, n=43) and normal subjects (control group, n=30). RESULT: The plasma vWF level was higher in MS group than that in MD group (P <0.05) and in control group (P <0.001); the vWF level in MD group was higher than that in control group (P <0.05). The NO level was lower in MS group and in MD group than that in control group (both P<0.05), while the difference between MS and MD groups was not statistically significant (P >0.05). Multiple stepwise regression showed that vWF level was correlated with systolic BP (SBP), diastolic BP(DBP) and pulse BP; that NO level was correlated with BMI, SBP and TG. CONCLUSION: Multiple metabolic disorders of metabolic syndrome may injure endothelial cells, and the degree of endothelial cell injury seems to be correlated with the BMI, SBP, DBP, pulse BP and TG.