| 低氧血症与SARS肝损伤的关系及还原型谷胱甘肽对肝损伤的疗效 |
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| 引用本文： | 胡水清,张泰昌,张玫. 低氧血症与SARS肝损伤的关系及还原型谷胱甘肽对肝损伤的疗效[J]. 中国新药杂志, 2004, 13(11): 1046-1048 |
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| 作者姓名： | 胡水清 张泰昌 张玫 |
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| 作者单位： | 首都医科大学宣武医院消化内科,北京,100053 |
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| 摘 要： | 目的:观察低氧血症与严重急性呼吸综合征(SARS)的关系及还原型谷胱甘肽(TAD)对SARS肝损伤的疗效.方法:对37例SARS并肝损伤患者予以TAD 600mg加入5%葡萄糖溶液250mL中静脉滴入,qd,2周为1个疗程;同时测定治疗患者的血氧分压,观察治疗前后肝功能(ALT,AST,TBil和GGT)变化及不良反应.结果:治疗前后肝功能(ALT,AST和GGT)差异有显著性(P<0.01),总有效率81.1%,无不良反应发生;低氧血症组ALT和AST明显高于血氧正常组,差异具有显著性;而TBil两组差异无显著性.结论:低氧血症与肝功能异常关系密切.TAD在治疗SARS肝脏损伤方面疗效显著且无不良反应.
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| 关 键 词： | 谷胱甘肽 严重急性呼吸综合征(SARS) 肝损伤 低氧血症 |
| 文章编号： | 1003-3734(2004)11-1046-03 |
The relationship between hypoxemia and SARS complicated liver injury and the efficacy of reduced glutathione in treatment of the disease |
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| HU Shui-qing,ZHANG Tai-chang,ZHANG Mei. The relationship between hypoxemia and SARS complicated liver injury and the efficacy of reduced glutathione in treatment of the disease[J]. Chinese Journal of New Drugs, 2004, 13(11): 1046-1048 |
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| Authors: | HU Shui-qing ZHANG Tai-chang ZHANG Mei |
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| Abstract: | Objective:To observe the efficacy of reduced glutathione (TAD) on SARS complicated liver injury. Methods: 37 patients with SARS complicated liver injury were treated with TAD 600mg once daily given by infusion after dissolved in 5% glucose injection for 2 weeks and their hepatic functions (ALT,AST,GGT) were determined before and after treatment. Results:The hepatic functions were significantly improved after treatment and the effective rate of reduced glutathione in this study was 81.1% ,no adverse drug reactions were observed.Conclusion:TAD show satisfactory therapeutic effect in treatment of SARS complicated liver injury. |
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| Keywords: | glutaththion SARS liver injury hypoxemia |
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