健脾解毒汤对晚期大肠癌患者生活质量的影响

目的观察健脾解毒汤对晚期大肠癌患者生活质量的影响。方法将60例晚期大肠癌患者随机分2组各30例,2组均采用相同的FOLFOX化疗方案治疗,治疗组同时加用健脾解毒汤治疗。2组均3周为1个周期,2个周期后观察2组中医临床证候疗效和治疗前后生活质量SF-36量表评分积分情况及不良反应。结果 2组中医临床证候疗效比较,治疗组、对照组总改善率分别为83.3%、60.0%,2组比较差异有统计学意义（P〈0.05）;生活质量SF-36量表评分,治疗组在总体健康、身体疼痛、活力、情感职能、精神健康、健康变化、生理职能等维度积分高于对照组（P〈0.05）。治疗期间治疗组血白细胞计数、血红蛋白下降程度低于对照组（P〈0.01,P〈0.05）。结论健脾解毒汤可以改善中医临床症状,减轻不良反应,提高生活质量,延长生存期。

Effect of Jianpijiedu decoction on the life quality of colorectai cancer patients in advanced stage

Objective To observe the effect of Jianpijiedu decoction on the life quality of colorectal cancer patients in advanced stage.Methods 60 patients with advanced colorectal cancer were randomly divided into treatment group and control group,30 cases in each group.Two groups were given the same FOLFOX chemotherapy.Patients in the treatment group added Jianpijiedu decoction during the treatment.The therapeutic course in two groups was 3 weeks.Traditional Chinese medicine clinical syndromes,the Chinese SF-36 scale score points for quality of life before and after treatment and adverse reactions were observed for evaluation of the effect after two courses.Results The total improvement rates of Traditional Chinese medicine clinical syndromes were 83.3% and 60.0% in treatment and control groups,the difference between the two groups was statistically significant（P0.05）.Quality of life on SF-36 scale of the treatment group in general health,bodily pain,vitality,emotional function,mental health,health changes,physiological functions of the dimension points were superior to those in control group（P0.05）.Adverse reactions during treatment in treatment group were significantly lower than those in the control group（P0.01,P0.05）.Conclusion Jianpijiedu decoction can improve clinical symptoms,reduce side effects,improve quality of life and prolong survival.