基于壳聚糖的医用可吸收止血贴的研究与应用

几丁质是自然界中合成的产量仅次于纤维素的天然有机化合物,其经过脱乙酰作用生成的壳聚糖具有优良的生物及化学性质;此外通过改变聚合度、脱乙酰度或经过不同官能团的修饰,壳聚糖的理化性质可以发生变化,因此它在生物医药和保健领域的应用倍受重视.本文首先叙述了壳聚糖及其衍生物与止血相关的性质与功能,说明了壳聚糖可作为止血贴主要材料的巨大应用价值,然后阐述了壳聚糖及其止血贴产品的研究现状与生产手段,最后依据目前研究现状,对基于壳聚糖的可吸收止血贴产品的未来发展趋势进行了展望.

Research and Application of Absorbable Wound Dressing Based on Chitosan

Chitin is a kind of organic compound which output is only inferior to the cellulose, and its product of chitosan possesses the fine biologic and chemical properties. Additionally the physicochemical property of chitosan varies through changing its polymerization and deacetylation degrees or being modified. At present chitosan are wildly used in bio-medical and health care fields. And chitosan preparations of various molecular weights, degrees of deacetylation and with further molecular derivatization patterns have attracted much attention because of their potentially beneficial biological properties. This paper first introduces the nature and function of chitosan and its derivative, which are related to hemostasis, and it is indicates that chitosan can be utilized as hemostasis materials widely. After that the research status of chitosan and means of production for chitosan hemostasis derivative are illustrated. Finally this paper presents the future trend of absorbable chitosan hemostasis would dressing.