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| 补髓生血颗粒对慢性再障患者骨髓单个核细胞MEK表达的影响 | |
| 引用本文： | 吴雷,孙岸弢,梁正贤,孙劲晖,王金环,孙伟正. 补髓生血颗粒对慢性再障患者骨髓单个核细胞MEK表达的影响[J]. 中医药信息, 2011, 28(3): 67-69 |
| 作者姓名： | 吴雷 孙岸弢 梁正贤 孙劲晖 王金环 孙伟正 |
| 作者单位： | 1. 黑龙江中医药大学,黑龙江,哈尔滨,150040 2. 中国中医科学院临床基础医学研究所,北京,100700 3. 台湾高雄县立冈山医院,台湾,高雄,82041 4. 北京中医药大学东直门医院,北京,100700 5. 黑龙江中医药大学附属第一医院,黑龙江,哈尔滨,150040 |
| 基金项目： | 国家自然科学基金重大研究计划，教育部高等学校博士学科点专项科研基金，教育部博士学科点基金资助，黑龙江中医药管理局基金项目，黑龙江中医药大学校科研基金资助 |
| 摘 要： | 目的：探讨补髓生血颗粒对慢性再障患者（CAA）骨髓单个核细胞中丝裂原活化蛋白激酶（MEK）表达的影响及其作用机制。方法：采用蛋白质印迹（Western-blot）方法检测CAA患者、正常人骨髓基质细胞MEK表达水平。结果：CAA患者骨髓单个核细胞的MEK表达水平均低于正常组（P〈0.05）,经补髓生血颗粒治疗后,MEK表达水平有所上升,与治疗前相比具有显著性差异（P〈0.05）。结论：CAA患者骨髓基质细胞MEK呈低水平表达,它有可能参与了CAA的发病机制过程;中药补髓生血颗粒可能是通过调节MEK的表达水平而促进MEK抗凋亡作用,从而影响骨髓造血信号转导调控,促进骨髓造血功能。 |
| 关 键 词： | 再生障碍性贫血 补髓生血颗粒 丝裂原活化蛋白激酶 |
The Effect of Busui Shengxue Granule on MEK Expressions of Bone Marrow Mononuclear Cells of Patients with Chronic Aplastic Anemia |
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| WU Lei,SUN An-tao,LIANG Zheng-xian,SUN Jin-hui,WANG Jin-huan,SUN Wei-zheng. The Effect of Busui Shengxue Granule on MEK Expressions of Bone Marrow Mononuclear Cells of Patients with Chronic Aplastic Anemia[J]. Information on Traditional Chinese Medicine, 2011, 28(3): 67-69 | |
| Authors: | WU Lei SUN An-tao LIANG Zheng-xian SUN Jin-hui WANG Jin-huan SUN Wei-zheng |
| Affiliation: | WU Lei1,SUN An-tao2,LIANG Zheng-xian3,SUN Jin-hui4,WANG Jin-huan5,SUN Wei-zheng5(1.Heilongjiang University of Chinese Medicine,Harbin 150040,China,2.Traditional Chinese Academy of Sciences Institute of Basic Medical Clinical,Beijin 100700,3.Kangshan Hospital of Kaohsiung County,Kaohsiung 82041,Taiwan,4.Dongzhimen Hospital of Beijing University of Chinese Medicine,5.The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,China) |
| Abstract: | Objective: To investigate Busui Shengxue Granule in patients with chronic aplastic anemia(CAA) in bone marrow mononuclear cells mitogen-activated protein kinase(MEK) expression and its mechanism.Methods: Western blotting(Western-blot) was detected by CAA,the expression of normal levels of bone marrow stromal cells MEK.Results: CAA bone marrow mononuclear cells of patients with MEK expression were lower than that in the normal group(P<0.05),by Busui Shengxue Granule after treatment,MEK expression levels incr... |
| Keywords: | Aplastic anemia Busui Shengxue granule Mitogen-activated protein kinase |
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