| 紫花高乌头总碱对实验性吗啡戒断症状的影响 |
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| 引用本文： | 杨玉梅,薛永志,刘和莉,李月玲,武海军,李艳玲,马瑞芳. 紫花高乌头总碱对实验性吗啡戒断症状的影响[J]. 中国民族医药杂志, 2007, 13(4): 46-48 |
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| 作者姓名： | 杨玉梅 薛永志 刘和莉 李月玲 武海军 李艳玲 马瑞芳 |
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| 作者单位： | 包头医学院药理教研室,包头,014010 |
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| 基金项目： | 内蒙古包头市医药卫生基金 |
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| 摘 要： | 目的:观察紫花高乌头总碱对吗啡戒断症状的影响。方法:采用剂量递增法复制吗啡依赖小鼠和大鼠模型,注射纳洛酮催促产生戒断症状。结果:紫花高乌头总碱可减少小鼠的跳跃反应,降低大鼠的戒断反应症状分值,不同程度的控制小鼠和大鼠的体重下降。结论:紫花高乌头总碱可抑制吗啡依赖动物的戒断症状。
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| 关 键 词： | 紫花高乌头总碱 吗啡 戒断症状 |
| 文章编号： | 1006-680O（2007）04-0046-03 |
| 收稿时间： | 2006-04-25 |
| 修稿时间： | 2006-04-25 |
Effect of Total Alkaloides of Aconitum excelsum Reichd on the Experimental Morphine-Withdrawal Syndromes |
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| Yang Yumei,Xue Yongzhi,Liu Heli,Li Yueling,Wu Haijun,Li Yanling,Ma Ruifang. Effect of Total Alkaloides of Aconitum excelsum Reichd on the Experimental Morphine-Withdrawal Syndromes[J]. Journal of Medicine & Pharmacy of Chinese Minorities, 2007, 13(4): 46-48 |
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| Authors: | Yang Yumei Xue Yongzhi Liu Heli Li Yueling Wu Haijun Li Yanling Ma Ruifang |
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| Affiliation: | Department of Pharmacology, Baotou Medical College, Baotou 014010 |
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| Abstract: | Objective:To study the effect of Tatal Alkaloides of Aconitum excelsum Reichd(AER) on the Morphine-Withdrawal syndromes in rat and mice.Methods:Rat and mice were given increasing doses of morphine to produce physical dependence and withdrawal syndromes were precipitated by im naloxone.Results:AER inhibited jumpus of mice and withdrawal syndromes of rat,and inhibited body weight loss for mice and rat in some degree.Conclusion:AER can inhibit morphine-withdrawal syndromes. |
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| Keywords: | Total Alkaloides of Aconitum excelsum Reichd Morphine Withdrawal syndromes |
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