Active immunization against hepatitis A in dialysis patients. |
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Authors: | Erwin Hermann Fleischmann Johannes Kruppenbacher Hans Ludwig Bock Manfred Weber |
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Affiliation: | Medizinische Klinik IV der Universit?t Erlangen Nürnberg, Virologisches Institut der Universit?t zu K?ln, Germany. |
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Abstract: | BACKGROUND: This study investigated the feasibility, immunogenicity, and reactogenicity of hepatitis A vaccination in end-stage renal failure patients who were on chronic intermittent haemodialysis. METHODS: Forty-three subjects were vaccinated with an inactivated hepatitis A vaccine according to a 0-, 1-, and 6-month immunization schedule. Two groups were established who received the vaccine either intramuscularly (group A, n=30) or subcutaneously (group B, n=13). RESULTS: All patients in group A and 12/13 in group B developed antibodies against hepatitis A. The geometric mean titres (GMT) were high and similar to those observed in healthy subjects. There was a tendency to higher GMT in the group who received the vaccine subcutaneously. No clinically significant adverse events were observed, and the liver enzyme profile showed no abnormalities. CONCLUSIONS: We showed that hepatitis A vaccination of dialysis patients is feasible, well tolerated and immunogenic and that the vaccine can be given subcutaneously in those patients where intramuscular administration is contra-indicated. |
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Keywords: | dialysis patients feasibility hepatitis A immunization immunogenicity reactogenicity |
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