序贯性血液净化抢救急性重症中毒28例

目的:探讨序贯性血液净化在抢救急性重症中毒患者中的作用.方法:对我院2002年来开展血液净化治疗28例急性重症中毒患者,序贯性运用血液灌注(HP) 连续性静脉-静脉血液滤过(CVVH)治疗,并作为血液净化组与我院1998～2002年未进行血液净化治疗的30例患者作回顾性对照研究.结果:血液净化组的患者在神志清醒时间、治愈率、死亡率以及阿托品用量等方面均明显优于非血液净化组.HP CVVH治疗优于单用HP治疗.结论:血液净化治疗在抢救各种毒物和药物重症中毒中具有重要作用;它能迅速缓解临床症状,有效提高抢救成功率,降低死亡率;HP CVVH尤其适用于伴有心肺功能衰竭、脑水肿、肾脏功能衰竭和电解质紊乱患者.

Treatment of sequential purification in rescuing acute grave intoxication: a report of 28 cases

Objective:To investigate the therapeutic effect of sequential blood purification on rescuing acute grave intoxication.Methods:Twenty eight patients with acute intoxication were treated by HP+CVVH during 2002 and compared them with thirty patients without hemopurgation from 1998 to 2002.Results:The group of hemopurgation was better than non-hemopurgation group in the time of revive,the rate of recovery and death,and the total dose of atropine.Conclusion:Hemopurgation has decisively effect on rescuing all kinds of intoxication with toxins and drugs.It could quickly ameliorate symptom,raise success rate and reduce mortality;Hp combining with CVVH are suitable for the patients with toxicsis who had cardiac and respiratory failure,brain edema,and dielectric disorder.