中药抗流感2号治疗甲型流感样发热聚集性病例的临床观察

目的探讨中草药在治疗甲型流感样发热聚集性病例的疗效以及安全性。方法针对包头聚集性发病人群的特点开展中草药治疗甲型流感样发热聚集性病例的疗效进行前瞻性研究。选择2009年包头市某大学聚集发热在校学生为研究对象,进行完全封闭、隔离、中草药抗流感2号口服治疗。系统观察患者服药当天及服药后第1、2、3、4、5、6天的体温变化、伴随症状以及患者的转归。结果 (1)703例患者遵医嘱进行了中药治疗,按时按量服药,无中途停药现象。服药后体温逐渐下降,体温陆续恢复正常,除了服药后第5天体温与服药后第6天体温很接近,无显著性差异外,其余相邻2 d的体温变化比较差异均有统计学意义(P0.01)。(2)发热患者服药天数与当天平均体温呈明显的线性相关关系,随着服中药时间延长,体温明显下降(P0.05)。(3)发热患者口服中药治疗后,随着体温的下降,伴随症状逐渐减轻,甚至缓解和消失。703例患者中,显效542例(77.1%),有效153例(21.8%),无效8例(1.1%)。结论中药抗流感2号治疗甲型流感样发热聚集性病例,具有明显的临床效果,安全性及依从性好,值得推广使用。

Clinical Observation of Influenza A - Like Fiver Aggregation Cases Treated with Chinese Herbal Medicine Kangliugan Erhao

Objective To explore the efficacy and safety on influenza - A like fever aggregation cases treated with Chinese herbal medicine. Methods Based on the characters of aggregation case group in Baotou,influenza - A like fever aggregation cases were treated with Chinese herbal medicine and the prospective study was conducted on the efficacy. The school students of aggregation fever were collected in one university in Baotou, 2009. Chinese herbal medicine, kangliugan erhao was used for oral administration in the completed isolation treatment. On the day of medication and on the lst ,2na ,3rd ,4th ,5th and 6th days after medication, the changes of body temperature, combined symptoms and outcomes of patients were observed systematically. Results （ 1 ） Seven hundred and third patients were advised to take Chinese medicine regularly and at dose, the medication was not discontinued on the halfway. After medication, the body temperature was re- duced gradually and recovered to be normal. Except the similar body temperature on the 5th and 6th days after medication, there were no significant differences. The differences in body temperatures on the rest of every two days were significant statistically（P 〈 0.01 ）. （2）The linear relationship presented between the days of medication and average body temperature each day. Along with the medication, the body temperature was reduced apparently（ P 〈 0.05 ）. （3）After oral administration of Chinese herbal medicine, while the body temperature was reduced, the combined symptoms were alleviated gradually, even relieved and disappeared. Of 703 cases ,542 cases （77.1% ）were remarkably effective, 150 cases （21.8%）effective and 8 cases （1.1% ） failed. Conclusion Chinese herbal medicine, kangliugan erhao achieves the obvious clinical effect on influ- enza A like fever aggregation cases, presenting good safety and compliance. Hence, this medicine deserves to be promoted in application.