Some new urinary metabolites of famprofazone and morazone in man |
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| Authors: | Neugebauer M |
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| Affiliation: | Pharmazeutisches Institut der Universität Bonn, Kreuzbergweg 26, D 5300 Bonn 1, Federal Republic of Germany |
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| Abstract: | The human urinary metabolism of two pyrazolone derivatives, morazone and famprofazone, has been investigated. After administration of morazone, the metabolites p-hydroxymorazone and phenazone-4-carboxylic acid were excreted in addition to the known metabolite, phenmetrazine, and unchanged morazone. Metabolism of famprofazone led to the formation of methamphetamine; the pyrazolone moiety was excreted as 3-hydroxymethyl-propyphenazone. |
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| Keywords: | Metabolism gas—liquid chromatography mass spectrometry morazone famprofazone phenmetrazine methamphetamine pyrazolone derivatives. |
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