绿茶抗脂蛋白氧化修饰作用的研究

目的]研究绿茶抗血浆脂蛋白氧化作用。方法]14名健康受试者空腹饮用绿茶后抽取静脉血，采用序列超速离心法分离血浆极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL），并观察各血浆脂蛋白过氧化程度以及氧化易感性的变化。结果]绿茶饮用后受试者VLDL、LDL和HDL过氧化脂质水平明显降低；在体外进行氧化修饰时，LDL氧化延滞时间明显延长，提示LDL氧化易感性下降。结论]绿茶可降低脂蛋白过氧化程度和增强LDL抗氧化修饰能力，因此能够起到防治心血管疾病的积极作用。

PROTECTIVE EFFECT OF GREEN TEA AGAINST OXIDATIVE MODIFICATION OF LIPOPROTEINS

Objective]To study the protective effect of green tea against oxidation of lipoproteins.Methods]The very low density lipoprotein(VLDL),low density lipoprotein(LDL)and high density lipoprotein(HDL)were isolated from fasted plasma by sequential ultracentrifugation before and after 14 healthy subjects had drunk green tea,then the degrees of peroxidation and susceptibilities of lipoproteins to oxidation were investigated.Results]The lipid peroxide levels of VLDL,LDL and HDL were significantly decreased after green tea intake;and the lag phages of LDL oxidation curves were prolonged noticeably in vitro,which indicated a reduced susceptibility to oxidation.Conclusion]Green tea,which can decrease the peroxidizability of lipoproteins and promote resistance to LDL oxidation,may be useful in the prevention and treatment of cardiovascular diseases.