| γ-氨基丁酸对精子顶体酶活性的影响 |
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| 引用本文： | 边淑玲,张玮,朱辉,倪江,姚兰春,陈亮. γ-氨基丁酸对精子顶体酶活性的影响[J]. 中华男科学杂志, 2002, 8(5): 326-328 |
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| 作者姓名： | 边淑玲 张玮 朱辉 倪江 姚兰春 陈亮 |
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| 作者单位： | 1. 哈尔滨医科大学,生理学教研室,黑龙江,哈尔滨,150086
2. 哈尔滨医科大学,附属第二医院不育症门诊,黑龙江,哈尔滨,150086 |
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| 基金项目： | 黑龙江省攻关课题 (GC0 1C14 2 0 1) |
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| 摘 要： | 目的 :研究γ 氨基丁酸 (GABA)对生育男性精子及抗精子抗体 (AsAb)阳性病人的精子顶体酶活性的影响。 方法 :用BAEE ADH联合法同时测定GABA对精子顶体酶活性的影响。 结果 :GABA可明显提高正常及AsAb阳性精子顶体酶的活性 (P <0 .0 1) ;并使精子的Na+ K+ ATPase、Ca2 + ATPase、超氧化物歧化酶 (SOD)的活性增加(P <0 .0 1,P <0 .0 5 ,P <0 .0 0 1)。 结论 :GABA对精子顶体酶活性有显著影响
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| 关 键 词： | γ氨基丁酸 精子 顶体酶 抗精子抗体 |
| 文章编号： | 1009-3591(2002)05-0326-03 |
| 修稿时间： | 2002-04-15 |
Effect of γ-Aminobutyric Acid on the Sperm Acrosin Activity |
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| Shu Ling BIAN ,Wei ZHANG ,Hui ZHU ,Jiang NI ,Lan Chun YAO ,Liang CHEN. Effect of γ-Aminobutyric Acid on the Sperm Acrosin Activity[J]. National journal of andrology, 2002, 8(5): 326-328 |
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| Authors: | Shu Ling BIAN Wei ZHANG Hui ZHU Jiang NI Lan Chun YAO Liang CHEN |
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| Affiliation: | Department of Physiology, Harbin Medical University, Harbin, Heilongjiang 150086, China. |
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| Abstract: | OBJECTIVES: To investigate the effect of gamma-aminobutyric acid (GABA) on the sperm acrosin activity in normal men and positive antisperm antibody (AsAb) men. METHODS: Sperm acrosin activity was detected by BAEE/ADH method. RESULTS: GABA could increase the sperm acrosin activity in normal and AsAb positive patients (P < 0.01). The results also indicated that GABA significantly increased Na(+)-K(+)-ATPase activity (P < 0.01), Ca(2+)-ATPase activity (P < 0.05) and SOD activity (P < 0.01) of sperm. CONCLUSIONS: The results demonstrated that GABA could influence the sperm acrosin activity. |
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| Keywords: | Gamma aminobutyric acid Sperm Acrosin activity Antisperm antibody |
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