流行性出血热三种单价灭活疫苗免疫后第5年预防效果

目的 观察流行性出血热（ｅｐｉｄｅｍｉｃ ｈｅｍｏｒｒｈａｇｉｃ ｆｅｖｅｒ，ＥＨＦ）沙鼠肾细胞Ｉ型灭活疫苗（沙鼠苗）免疫后第５年、乳鼠脑纯化Ｉ型灭活疫苗（鼠脑苗）免疫后第４年和地鼠肾细胞Ⅱ型灭活疫苗（地鼠苗）免疫后第５年在ＥＦＨ疫区试验人群中的安全性、血清学效果和预防效果。方法 现场试验人群采用整群随机分组，分为疫苗接种组和对照组。实验室血清标本检测采用间接免疫荧光法（ＩＦＡＴ）、微量细胞病变中

Preventive effects of three kinds of inactive vaccines against epidemic hemorrhagic fever (EHF) after 5 years of vaccination

Objective To observe the safety and the preventive effects of three kinds of vaccines as Mongolian gerbils kidney vaccine, mouse brains vaccine and hamster kidney vaccine inoculated 5 years ago. Methods Field study and laboratory tests were carried out by random grouping and IFAT,MCPENT,ELISA,HI tests. Results The antibody-dependent enhancement did not appear in all individuals who received vaccines after four or five years. The seroconversion rates of MCPENT were 8.97 %, 11.76 % and 18.75 % while the seroconversion rates of IFAT were 20.73% , 30.22 % and 23.40 % respectively for Mongolian gerbils kidney vaccine, mouse brains vaccine and hamster kidney vaccine. The protection rates were 100% for all three kinds of inactive vaccines which showed good epidemiological efficacy. Conclusion The vaccines can protect clinical infection of EHF effectively after four or five years of the initial vaccination.