| 2,4-二氨基-5-甲基-6-(N-甲基取代苄氨基)喹唑啉的合成及其抗肿瘤和抗菌作用 |
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| 引用本文： | 蒙小英,张秀平,陈秀华,余爱珍. 2,4-二氨基-5-甲基-6-(N-甲基取代苄氨基)喹唑啉的合成及其抗肿瘤和抗菌作用[J]. 药学学报, 1991, 0(5) |
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| 作者姓名： | 蒙小英 张秀平 陈秀华 余爱珍 |
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| 作者单位： | 上海医药工业研究院，上海医药工业研究院，上海医药工业研究院，上海医药工业研究院 上海 200433，上海 200433，上海 200433，上海 200433 |
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| 基金项目： | 国家自然科学基金 No 2860202 |
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| 摘 要： | 作者曾报道2,4-二氨基-5-甲基-6-取代苄氨基喹唑啉衍生物有较好的抗疟和抗肿瘤作用。鉴于在2,4-二氨基-6-取代苄氨基喹唑啉的6位侧链氨基上引入甲基,可使抗肿瘤活性明显增强,因此设计合成了一系列2,4-二氨基-5-甲基-6-(N-甲基取
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| 关 键 词： | 氨基喹唑啉 抗肿瘤活性 抗菌活性 |
SYNTHESIS AND ANTIBACTERIAL AS WELL AS ANTINEO-PLASTIC ACTIVITIES OF 2,4-DIAMINO-5-METHYL-6-(N -METHYL-SUBSTITUTED BENZYL)AMINOQUINA-ZOLINES |
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| XY Meng,XP Zhang,XH Chen and AZ Yu. SYNTHESIS AND ANTIBACTERIAL AS WELL AS ANTINEO-PLASTIC ACTIVITIES OF 2,4-DIAMINO-5-METHYL-6-(N -METHYL-SUBSTITUTED BENZYL)AMINOQUINA-ZOLINES[J]. Acta pharmaceutica Sinica, 1991, 0(5) |
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| Authors: | XY Meng XP Zhang XH Chen AZ Yu |
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| Abstract: | This paper reports four methods for the synthesis of 2,4- diamino- 5 - methyl - 6 - ( N- methyl - substitutedbenzyl) aminoquinazolines. Six compounds were synthesized and all these compounds showed good anticancer and antibacterial activities. Among them, I_5 showed the strongest inhibition against L1210 Leukemia cell and further research has to be done. |
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| Keywords: | Aminoquinazoline Antineoplastic activity Antibacterial activity |
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